Personnel Listed on Your Protocol
Once Your Protocol Is Approved
Grant Proposal Submission Information for UNC Charlotte
Protocol Submission Information
The following types of activities require IACUC review and approval:
- A course using vertebrate animals in teaching.
- Any research, research training, experimentation, biological testing, and related activities involving live vertebrate animals and conducted at this Institution, or at another institution as a consequence of the sub-granting or subcontracting of a Public Health Service (PHS) conducted or supported activity by this Institution.
- Any research involving intact animal cadavers (i.e., whole dead body of a warm-blooded animal) from an extramural (i.e., non-UNC Charlotte) source.
- Field studies involving trapping, capturing, physical/chemical restraint, and/or invasive procedures.
Click on the following link to access Word-based Amendment form for all changes to IACUC-approved protocol applications such as:
- addition/removal of personnel;
- change in procedures;
- change in PI;
- changes in use of anesthetics/analgesics;
- addition of animals.
Please refer to the IACUC Policy “Amendments: Classifications and IACUC Review Processes” for more detailed information on what constitutes minor and major amendments and what review procedures are involved with both types of amendments.
You must have an Animal Care Application reviewed and approved by the IACUC BEFORE you can order or begin research/work using live vertebrate animals.
For educational observational studies: You will need to complete the Protocol for Educational Observational Studies for IACUC review and approval PRIOR to use of animals in teaching lectures or laboratories. You will receive formal approval notification from the IACUC via the Office of Research Compliance.
Before an individual is permitted to work with live animals, he or she must complete the following to be deemed “cleared” to engage in animal research or animal care activities:
- Completion of online educational modules via the CITI system;
- Completion of a Basic Health History Form (BHHF) to include the most recent tetanus immunization date for enrollment in the Occupational Health program and subsequent clearance by the Occupational Health Physician;
- Completion of orientation training for the Vivarium with the Attending Veterinarian/Director of Laboratory Animal Resources
- Inclusion on an Animal Care Application as study personnel with specific roles and duties assigned related to the research proposed in the Application.
These requirements apply for ALL faculty, staff, post-doctoral fellows, students, and anyone else handling or exposed to live vertebrate animals. In addition, these requirements also apply to foreign students or visiting fellows or faculty, summer students, and high school students working in labs where animal research is being conducted.
NOTE: Application approval will be held until all personnel listed on the application have completed all animal care and use personnel requirements.
No. Each species must be covered under a separate application.
If you are obtaining animal tissue from another investigator on campus or from another source, you do not need to register your research with the IACUC. However, please contact the Office of Research Compliance at (704) 687-1872 to determine whether the office needs to obtain records from the “source” institution to verify that you are using animal tissue which has been approved and regulated by that institution’s animal care and use program.
If you intend to purchase live animals to be brought to UNC Charlotte in order to euthanize them and collect tissue for research purposes, an application must be completed and submitted to the IACUC for review and approval.
Federal regulations require that animals to be purposely bred for research be approved through and monitored by the IACUC.
It is good practice to submit an IACUC application between 30 and 60 days before you expect to receive notification of funding status regardless of the sponsor.
For grant proposals submitted to any of the Centers or Institutes at the National Institutes of Health (NIH), you can submit an IACUC application EITHER when you receive “Just-In-Time” funding notification OR prior to award release. Per the NIH Grants Policy, an IACUC protocol consistent with the grant’s experimental aims and objectives associated with animal research must be approved prior to release of award funds.
IACUC applications are approved for 3 years and must be reviewed annually. Annual renewal forms are submitted via a Word-based form which can be found by clicking here.
If a PI wants to continue a research study beyond the 3-year “life cycle” of IACUC approval, a new de novo application must be submitted to the IACUC for review and approval.
All new and de novo applications where proposed animal use activities could cause more than momentary animal pain and/or distress must first be discussed with the Attending Veterinarian (AV) PRIOR to submission to the IACUC. Please allow 1-2 business weeks for initial AV consultation. If there are no special considerations or requests associated with the application (i.e. performing research at a USDA pain/distress Category E level or requesting exceptions to regulatory/institutional policies) applications are then distributed to the full IACUC electronically for initial review and determination of formal review process (e.g. review by a Designated Member Reviewer [DMR] or Full Committee Review [FCR] at a convened meeting). Depending on the subsequent process chosen, further review could take an additional 2-4 weeks. The IACUC meets on a monthly basis. Please see IACUC Meeting Schedule to view the current meeting dates and submission deadlines.
NOTE: Review times mentioned here are average times and the review may take longer depending on how quickly investigators work with the IACUC and ORC to resolve questions and respond to review comments. Investigators are asked to carefully consider their research schedule and allow adequate time for IACUC review. Animal research may not begin until IACUC approval is obtained.
For animal care/use protocols which involve use of biohazards, chemical hazards, or radiation hazards, a concurrent application/submission will need to be sought from either the Institutional Biosafety Committee (for biohazards) or the Environmental Health and Safety Office (for chemical and/or radiation hazards). PIs must have these approvals in place BEFORE the IACUC can approve the protocol.
Contact the Office of Research Compliance if you are not sure whether additional compliance or regulatory approvals are needed. PIs should plan submissions accordingly and should note that a longer timeframe may be involved to procure all approvals.
All hazardous agents to be used in animals should be listed in Appendix D and submitted along with the core experimental protocol form or the breeding protocol form. Consult with the Attending Veterinarian before submitting an application or amendment proposing use of such agents for full IACUC review. Finally, consult with the Office of Research Compliance (ORC) at (704) 687-1872 to see if concurrent protocol submissions to other compliance committees is required or to obtain additional information about safety and/or regulatory requirements needed before acquiring and using these materials.
Personnel Listed on Your Protocol
Include all people who will have a major role in conducting the research, such as the PI and research personnel performing procedures on live animals (i.e. surgical procedures; tumor/test article injections; genotyping; oral gavage, etc.).
IACUCs must determine that all personnel conducting proposed activities are qualified and trained per AWA Regulation 2.31(d)(1)(viii) and PHS Policy C.1.f: “Personnel conducting procedures on the species being maintained or studied will be appropriately qualified and trained in those procedures.” Please refer to this link for the AWA Regulations and to OLAW guidance on its Frequently Asked Questions page FAQ G.1.
All personnel who will be handling, and performing procedures on live animals must be trained appropriately and qualify to be listed on an IACUC protocol. Requirements for working with animals include completion of all applicable CITI training modules, enrollment in the occupational health program via completion and submittal of a health history form with clearance from the Occupational Health Physician (OHP), and an orientation to the Vivarium. The student must also be listed on any/all relevant IACUC protocols.
For students performing work on animal tissue in the PI’s lab (blood, organs, whole carcass), the “Working with the IACUC” CITI module must be completed as well as enrollment in the occupational health program via submission of the health history form.
For students who only will be performing in vitro work but still may be exposed to animal research being performed around them in a lab, a quick orientation to the basic animal care/use regulatory environment and potential occupational health risks associated with working in such a lab must be completed prior to beginning work in the lab. Orientation can be arranged through the Office of Research Compliance (ORC) at (704) 687-1872.
Once Your Protocol Is Approved
You will be asked by animal care staff to complete an Animal Order Form. Contact the Vivarium at (704) 687-8318 for more information on ordering animals.
All attempts will be made to honor requests for visits to the Vivarium. Visitors will be asked to sign a log book which contains a few simple assurance statements to which the visitor agrees upon entry. Personal protective equipment (PPE) provided by the Vivarium must be worn when entering procedural or animal holding areas.
Visitors who have been in other animal facilities housing rodents or who have rodents as pets will be asked to refrain from entering the Vivarium for 48 hours after last exposure.
Contact the Vivarium at (704) 687-8318 for more information or to schedule a visit.
Grant Proposal Submission Information for UNC Charlotte
D16-00363 (formerly A3600-01)
Robert G. Wilhelm, Ph.D. is the Institutional Official (IO). Dr. Wilhelm also serves as the Vice Chancellor for Research and Economic Development for the University.
The Compliance Office is located on the 3rd floor of the Cameron Hall. Signs are posted at the entrances to the 3rd floor suite of offices.
Institutional Animal Care and Use Committee
c/o the Office of Research Compliance
9201 University City Boulevard
Cameron Hall Third Floor
Charlotte, NC 28223-0001
FX: (704) 687-0980
IACUC Compliance Manager: Cindy Stone
327 Cameron Hall
PH: (704) 687-1872
Associate Director, Office of Research Compliance: Barry Rowan
320 Cameron Hall
PH: (704) 687-8270
Contact any of the following:
- The Associate Director of the Office of Research Compliance (ORC) at (704) 687- 8270, via fax at (704) 687-0980 or by email.
- The Attending Veterinarian at (704) 687-5017 or
- The Chair of the Institutional Animal Care and Use Committee (IACUC) at (704) 687-8696.
Animal welfare concerns can be reported anonymously. The information you provide will be promptly investigated. Should you choose to identify yourself, your identity will remain confidential to all other parties in the University and any other entities to which the University is required to report substantiated claims of unethical use or mistreatment of animals in the animal care and use program.
NOTE: UNC Charlotte prohibits retaliation or sanctions against any individual who brings allegations of animal misuse, cruelty, or any other animal welfare concern to the attention of ORC, anyone else in the animal care and use program, or University administration (see University Policy #803: “Reporting and Investigation of Suspected Improper Activities and Whistleblower Protection”).